Creating Anti-HIV-Infection effect by Synthesis of AuNPs from Rosa canina L. Fruit Extract
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چکیده
AuNPs have been in the focal point of researchers’ attention for years because of high biocompatibility and adjustable surface plasmon resonance (SPR) [1]. In the recent years, many studies have been performed in producing AuNPs via green synthesis techniques, i.e. use of plants for producing AuNPs [2]. Green synthesis methods are eco-friendly and increase the biocompatibility of AuNPs [3]. A factor that gives rise to the highest difference between various gold nanoparticle characteristics is the size of synthesized AuNPs and their superficial compounds [4]. Rosa canina fruit extract has immunomodulatory characteristics with probable potential to be used in treatment of immunodeficiency diseases [5]. Rosa canina fruit extract, can reduce initial gold salt – chloroauric acid – and produce gold colloid. The major components of this plant are Vitispiran, 5-Methyl-3-hexanone, 2-Heptanone, Hexadecanoic and Dodecanoic acid, Linolic acid, α-E-Acaridial, Myristic acid, Benzaldehyde, α-pinene, 2-pentylfuran, 2,4-Heptadienal, 1,4-Epoxy-p-menthane, Salicylaldehyde, 2-Heptenol and Linalool [6]. In this research, nanoparticles were produced via a novel green method and capped with Rosa canina fruit extract. Then, the antiretroviral effects of these nanoparticles were investigated. Size stability of AuNPs in physiological condition (pH = 7.4) is the necessary condition for their application in medicine [7]. The stability of AuNPs produced using Rosa canina fruit extract and nanoparticles produced through the conventional sodium citrate reducing agent in pH = 7.4 was thus compared. After the human immunodeficiency virus (HIV-1) enters the body and the blood circulatory system, its superficial glycoproteins, gp120 and gp41, bind with receptors like CD4 and CCR5 on the surface of T-Lymphocytes. By sending its capsid into T-lymphocytes, this virus inducts its RNA together with enzymes, such as reverse transcriptase, integrase and protease into the cell, allowing them to start an operation that will force the T-cells to produce new HIVs. Because of the high infection volume of this disease, antiretroviral drugs are employed to control its advance. Most of these drugs are transcriptase inhibitors [8], integrase inhibitors [9] and protease inhibitors [10], although they cannot be completely effective, because of HIV’s resistance to drugs. The purpose of this study was to use the new reducing agent Rosa canina fruit extractto Volume 6 Issue 3 2017
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